It is not entirely clear what you want advice on. If you have specific questions about how to use the Wixel, we would prefer to continue discussing it here. If you are asking for more general engineering advice, that kind of advice is typically beyond the scope of our technical support.
The Wixel does support I2C; you can find an example in the "Serial-to-I²C App" section of the Wixel user's guide.
We do not have an ActiveX control for the Wixel with VB. You should be able to communicate with the Wixel from your VB code through the virtual COM port without it. You might find this reference page from Microsoft helpful.