removing the pot is not a terrible hassle, but it is enough fiddly to discourage that as a means of approaching the situation (since it's not just the work, but also the fact I can't be certain a thin gauge wire wouldn't be a weak point in the design.) It's only doable for my at-home hobby work.
I've just considered it in the past but found other methods to deal with the situation. For example, where I work I'm occasionally doing one-off designs involving your boards so there are only a few units made yearly. That's one of the reasons we use the breakout boards instead of rolling our own (and, your boards are great quality and hardly more expensive than rolling our own.) So in the end we only use 16-32 of your stepper driver boards in a year at this rate. Once you count all the other types of boards you offer it ends up being 25-50, I'm guessing. Not a big amount.
I tend to do something where I have a PCB socket for your parts, to simplify wiring and replication for the future units, if I'm not around next year and they want to make a few more units.
At the moment I just document things well, and have made some thorough "how to set the potentiometer" docs for assembly here. But a much nicer approach for me would be to just declare some trace that needs to be cut and plug the board into my master MCU pcb board, and control a digital potentiometer in code. This would be(much easier than desoldering anything, and much much easier than asking people to set the mechanical potentiometer which can be done poorly and can theoretically shift. So I'm not particularly inclined to think there's a massive demand for another DRV8825 board with a digital potentiometer on board. Thanks for linking the other thread, I hadn't noticed it. EDIT: Hehe, I had not noticed, but I responded to that thread a long time ago when it was first listed.
As I mentioned, I think it could potentially be done with just a clear trace to be cut ( representing 3.3V-mechanical pot leg high-side) to bypass the existing pot, and a through-hole along an unused edge, where that pin goes to where the output leg of the current mechanical pot goes. This way the board could 100% be used in the existing manner that people use them all the time, and also have the ability to be easily adapted for an external digital potentiometer. Or even just so that if people want to string multiple of the boards to similar stepper motors, they could cut the traces on them all, and set them with one external pot.
But I have no idea how much money it would take for such a design change, how much one extra hole would cost in production, and whether such (relatively limited) modification could fit on the existing form-factor.