A typical PC does not have the sort of general purpose output pins that are needed to control an SK6812 LED strip directly. If you want to control an SK6812 LED strip from your computer, I would recommend getting an A-Star programmable controller and running the PololuLedStrip library on it. You would use the A-Star's USB interface to receive commands from the PC and use the PololuLedStrip library to update the LEDs.
You would have to write some C++ code on the A-Star to process the serial commands. A good starting point for the A-Star code would be the LedStripColorTester example that comes with the library, since it shows how to receive a color over USB and then send that color to the LEDs.
On the PC side, you can use the .NET SerialPort class to send commands to the A-Star.
Another option to consider would be to get a Raspberry Pi computer, install Windows 10 IoT Core on it, and then write .NET code on the Raspberry Pi to control an LED strip directly through the Raspberry Pi's GPIO pins. You would want to use an APA102-based LED strip instead of an SK6812 one, because the SK6812 strips require very precise timing that is probably not possible with an operating system like Windows.